>Koch's postulates (/ˈkɔːx/)[2] are four criteria designed to establish a causative relationship between a microbe and a disease. The postulates were formulated by Robert Koch and Friedrich Loeffler in 1884, based on earlier concepts described by Jakob Henle,[3] and refined and published by Koch in 1890.[citation needed] Koch applied the postulates to describe the etiology of cholera and tuberculosis, both of which are now ascribed to bacteria. The postulates have been controversially generalized to other diseases.[citation needed] More modern concepts in microbial pathogenesis cannot be examined using Koch's postulates, including viruses (which are obligate cellular parasites) and asymptomatic carriers.[citation needed] They have largely been supplanted by other criteria such as the Bradford Hill criteria for infectious disease causality in modern public health,[citation needed] and Falkow's criteria for microbial pathogenesis.
>>Koch's postulates (/ˈkɔːx/)[2] are four criteria designed to establish a causative relationship between a microbe and a disease. The postulates were formulated by Robert Koch and Friedrich Loeffler in 1884, based on earlier concepts described by Jakob Henle,[3] and refined and published by Koch in 1890.[citation needed] Koch applied the postulates to describe the etiology of cholera and tuberculosis, both of which are now ascribed to **bacteria**. The postulates have been controversially generalized to other diseases.[**citation needed**] More modern concepts in microbial pathogenesis cannot be examined using Koch's postulates, including viruses (which are obligate cellular parasites) and asymptomatic carriers.[citation needed] They have largely been supplanted by other criteria such as the Bradford Hill criteria for infectious disease causality in modern public health,[citation needed] and Falkow's criteria for microbial pathogenesis.
https://en.wikipedia.org/wiki/Koch%27s_postulates
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