I watch this Glenn Fricker guy on YouTube and he is funny, he gets excited, anyways, he goes on and on and on about the biggest difference in your tone is not the pick up or the string or the wood, it is all the speaker
I'd contest that the speaker is not part of the guitar, so is irrelevant to the question of what part of the guitar impacts tone the most.
Of course the amp and speakers matter, as do effects pedals... Trying to cop out like that is just trying to be smart without actually being smart.
He does blind tests with different guitars through the same amps with different speakers
Yeah, the speakers can/will impact tone quite a bit. There are a bunch of popular replacements - including boutique speaker makers that will craft you something custom.
That the speakers change the tone is not argued (by sensible people).
Oh, here's a fun link:
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