I went to grade school with a kid damaged by thalidomide. He was bright and friendly but had multiple congenital limb deformities. It was originally touted for morning sickness and then the babies started being born without limbs. Lots of these babies were left to simply die (like China's dying rooms) but some parents chose to raise their damaged babies. There's a prenatal test called chorionic villus sampling performed to evaluate genetic anomalies that actually *causes* limb deformities or total absence of.