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Update: UPDATE: Janssen / Johnson & Johnson COVID shot is an RNADNA shot.

I have this nagging question which I'm sure I can answer searching Poal, but I'm writing it down here. In the US there are four firms about whom we hear much about the COVID injections. "Mechanism of action," is a pharmacology phrase you can search for which describes how these things work. In all cases they appear to work the same way by causing cells to create Sars-CoV2 S1 spike protein sub-unit antigen. I invite you to share your knowledge, but the questions I'm working on include:

1) Why are competing firms all, effectively, doing the exact same thing? They can argue that their products are different, but it appears to me that the difference is merely in how the payload is delivered rather than what the payload is. I did not find a formula for the RNA molecule in the linked documents, but both Pfizer and Moderna use the identical phrase, "nucleoside-modified messenger RNA (modRNA)." I feel rather certain that two competing firms would not select that exact turn of phrase to identify this component of their product were it a point of differentiation between them. For this reason I believe that the, "secret sauce," is identical.

2) Do the viral vector injections from J&J and AZ also contain, "nucleoside-modified messenger RNA (modRNA)" in their viral vector products? These documents lack this phrase - perhaps because the nucleoside-modified messenger RNA (modRNA) is grafted upon the virus and is thus part of that package rather than standing alone in a non-viral vector?

3) Assuming top-scientists are contributing to these products for these companies, why have they all arrived at the same conclusion that the way to immunize a person is through the immune response to expression of S protein by the patient? More likely they all picked the same mechanism of action because it was a) easy and handed to them or b) required of them.

4) Are all these firms creating their own proprietary RNA molecule which happens to express the same S1 subunit protein? Can many different RNA molecules create the expression of the same protein?

5) Are these firms licensing nucleoside-modified messenger RNA (modRNA) for use in their product? If so, from whom? If not, who are the suppliers for the active ingredient?

Spike Protein Names by Vendor: Pfizer: "S glycoprotein of SARS-CoV-2" Moderna: "SARS-CoV-2 S antigen" J&J: "SARS-CoV-2 spike (S) antigen" AZ: "S glycoprotein of SARS-CoV-2"

False choices are the new, "Freedom": - Lipid Nanoparticle or Viral Vector for your SARS-CoV-2 S antigen - Republican or Democrat - CNN or CNBC - Toilet that won't flush a turd with a round seat, or with an oval seat

It's all so tiresome.

Update: [AZ is a DNA shot](https://archive.is/AZ4p4) UPDATE: Janssen / Johnson & Johnson COVID shot is an ~~RNA~~DNA shot. I have this nagging question which I'm sure I can answer searching Poal, but I'm writing it down here. In the US there are four firms about whom we hear much about the COVID injections. "Mechanism of action," is a pharmacology phrase you can search for which describes how these things work. In all cases they appear to work the same way by causing cells to create Sars-CoV2 S1 spike protein sub-unit antigen. I invite you to share your knowledge, but the questions I'm working on include: 1) Why are competing firms all, effectively, doing the exact same thing? They can argue that their products are different, but it appears to me that the difference is merely in how the payload is delivered rather than what the payload is. I did not find a formula for the RNA molecule in the linked documents, but both Pfizer and Moderna use the identical phrase, "nucleoside-modified messenger RNA (modRNA)." I feel rather certain that two competing firms would not select that exact turn of phrase to identify this component of their product were it a point of differentiation between them. For this reason I believe that the, "secret sauce," is identical. 2) Do the viral vector injections from J&J and AZ also contain, "nucleoside-modified messenger RNA (modRNA)" in their viral vector products? These documents lack this phrase - perhaps because the nucleoside-modified messenger RNA (modRNA) is grafted upon the virus and is thus part of that package rather than standing alone in a non-viral vector? 3) Assuming top-scientists are contributing to these products for these companies, why have they all arrived at the same conclusion that the way to immunize a person is through the immune response to expression of S protein by the patient? More likely they all picked the same mechanism of action because it was a) easy and handed to them or b) required of them. 4) Are all these firms creating their own proprietary RNA molecule which happens to express the same S1 subunit protein? Can many different RNA molecules create the expression of the same protein? 5) Are these firms licensing nucleoside-modified messenger RNA (modRNA) for use in their product? If so, from whom? If not, who are the suppliers for the active ingredient? [Astra Zeneca - European Medicines Agency](https://www.ema.europa.eu/en/documents/product-information/covid-19-vaccine-astrazeneca-product-information-approved-chmp-29-january-2021-pending-endorsement_en.pdf) [Moderna](https://www.modernatx.com/covid19vaccine-eua/eua-fact-sheet-providers.pdf) [Janssen](https://www.janssenlabels.com/emergency-use-authorization/Janssen+COVID-19+Vaccine-HCP-fact-sheet.pdf) [Pfizer](http://labeling.pfizer.com/ShowLabeling.aspx?id=14471) Spike Protein Names by Vendor: Pfizer: "S glycoprotein of SARS-CoV-2" Moderna: "SARS-CoV-2 S antigen" J&J: "SARS-CoV-2 spike (S) antigen" AZ: "S glycoprotein of SARS-CoV-2" False choices are the new, "Freedom": - Lipid Nanoparticle or Viral Vector for your SARS-CoV-2 S antigen - Republican or Democrat - CNN or CNBC - Toilet that won't flush a turd with a round seat, or with an oval seat It's all so tiresome.

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So I thought that too, when you say, "traditional..." Such as a deactivated polio virus being part of your polio vaccine. However, the Janssen J&J shot is, "replication-incompetent human adenovirus" - not a corona virus or COVID-19 virus. I think the virus is used as the means to gain entry to the cell, but the end result is that the cell is then generating the SARS-CoV-2 spike (S) antigen exactly as if you had been injected with Moderna. A virus works by entering a cell and causing the cell to replicate virus through the introduction of RNA into the cell by the virus (or other means depending on the virus). The part which is left out of J&J and AZ is whether the adenovirus has been engineered to deliver the same nucleoside-modified messenger RNA (modRNA) contained in the mRNA alternatives. My suspicion is that this is exactly the same which is evidenced by the overlap of these key phrases between the different vendors.

Moderna causes expression of "SARS-CoV-2 S antigen" <-- mRNA J&J causes expression of "SARS-CoV-2 spike (S) antigen" <-- viral vector

AZ, which is also viral vector does not have the word, "RNA," in their label. However, the AZ hints at this with, "vector encoding the S glycoprotein of SARS-CoV-2." You will note that the italicized part is the exact phrase which Pfizer uses in their description of the protein which is caused to be expressed in their shot.

AZ and Pfizer describe the protein expressed word-for-word the same way. J&J and Moderna describe the protein expressed in nearly the same way Moderna and Pfizer describe the RNA molecule word-for-word the same way.

So where I'm going is that they're all the same. Exactly. Maybe different dosing, maybe different efficiency in uptake of the nucleoside-modified messenger RNA (modRNA), but it appears to me that they are all using nucleoside-modified messenger RNA (modRNA). I'm trying to confirm that.