So AOS >Original Antigenic Sin: How First Exposure Shapes Lifelong Anti–Influenza Virus Immune Responses Can be any virus or vaccine, the developed antibodies only to the spike protein and can’t fight the rest of the virus. >The British are now finding that the vaccine alters the body's ability to produce antibodies after infection, not only against the spike protein, but also against other parts of the virus. **In particular, vaccinated people do not appear to produce antibodies to the nucleocapsid protein, the virus envelope, which is a crucial component of the response in unvaccinated people**.