> PCR tests are used to diagnose covid19
You are missinng the crux of the entire debate. Really.
They are saying the levels of the virus likely to lead to infection will show up after 25 or 30 cycles.
If you only can get a positive after 35 or 40 cycles, the subject has a quantity of virus that will not likely lead to infection! So, according to some experts, we shouldn’t care about those positives.
They are saying the PCR test will work better as a test for infection if you reduce it’s sensitivity.
Confirmation of infection would be if your viral load increased on a subsequent PCR after 48 hrs or if you got symptoms.
You don’t need any other test. Antigen test wont work for at least 2 or 3 weeks. You need to correlate postive test result at 25 cycles (or 30 or 35) to probability of increased viral load after a second subsequent test, or development of symptoms or development of antigen. Then you can gauge the goodness of the PCR test at various cycle thresholds as a predictor of contagiousness or disease state.
>They are saying the levels of the virus likely to lead to infection will show up after 25 or 30 cycles.
No that's not what they say
https://www.rt.com/op-ed/507937-covid-pcr-test-fail/
>This is not the first challenge to the credibility of PCR tests. Many people will be aware that their results have a lot to do with the number of amplifications that are performed, or the ‘cycle threshold.’ This number in most American and European labs is 35–40 cycles, but experts have claimed that even 35 cycles is far too many, and that a more reasonable protocol would call for 25–30 cycles. (Each cycle exponentially increases the amount of viral DNA in the sample).
>Earlier this year, data from three US states – New York, Nevada and Massachusetts – showed that when the amount of the virus found in a person was taken into account, up to 90 percent of people who tested positive could actually have been negative, as they may have been carrying only tiny amounts of the virus.
>The Portuguese judges cited a study conducted by “some of the leading European and world specialists,” which was published by Oxford Academic at the end of September. It showed that if someone tested positive for Covid at a cycle threshold of 35 or higher, the chances of that person actually being infected is less than three percent, and that “the probability of… receiving a false positive is 97% or higher.”
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