Engineered like chimeric viruses: The replication mechanism from one virus, infection mechanism from another, immune system suppression from a third, payload created from scratch and so on. A virus RNA sequence consist of maybe 30K of information (of how the resulting proteins are formed), and some of that information is even compressed like a zip file (parts of the sequence are used for more than one resulting protein). This is still way too complicated and not understood enough to do it from scratch, even if they already can create the first virus like particles that can replicate. Maybe an AI can do that one day - until then, the bioweapon labs are operating in some kind of Frankenstein mode (putting parts together). That's why you find patented sequences in SARS-2, or why Omicron works better with mice than with human cells.
It has, millions of times. There are machines that create RNA molecules out of the RNA sequences stored in computers. There are machines that create the proteins encoded in these RNA molecules. You can put such proteins into the nose of a mouse and they replicate and infect other mice. This can be proven by adding luciferase creating genes to the virus sequence before creating the RNA. The luciferase (firefly light) gets created in every infected cell - the mouse starts to glow. And, after some time, the mice around. Even biology students can do that, it's part of their training with biomarkers.
If it was isolated they wouldn't have to do all that. Their evidence is: look a cytotoxic effect, it must be a virus.
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