Nicotine causes weight loss and has strong anti-depressant effects. I don't think I'm ever going to diet again. At most you can yoyo your weight on a diet, but it always seems to come back. Nicotine takes it off and it doesn't come back, at least while you're still using nicotine. The whole argument that diet causes obesity is questionable to me. I think it's more likely there's something poisonous in junk food that permanently damages people's ability to regulate weight. Weight is regulated by the hypothalamus, so there could be something poisonous in the food that damages the brain and that's the underlying cause of the obesity epidemic. Here's something I noticed in the past. If I ate junk food from the grocery store I gained weight from it readily. If I made junk food from scratch, I didn't gain weight from it. It seems clear to me there's something in the premade food that shouldn't be in it, maybe it's a preservative, a food coloring, or something else.